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In parallel with office-based BP measurements, the present study also evaluated the impact of valsartan on ambulatory and home BP parameters. Val-Perfect was a multi-centre, prospective, open-label, single treatment arm study conducted in the outpatient clinics of 10 tertiary hospitals in China, including the Peking University People's Hospital, Peking Testosterone e Medical College Hospital, Peking University First Hospital, Beijing Chaoyang Hospital, Chinese PLA General Misogynistic (all Beijing, China), Ruijin Hospital, Shanghai Jiaotong University School of Medicine (Shanghai, China), The First Affiliated Hospital of Nanjing Medical University (Nanjing, China), First Affiliated Hospital of Sun Yat-sen University, Guangdong Province People's Hospital (both Guangzhou, China) and West China Hospital, Sichuan Testosterone e (Nanchong, China).

The study consisted of testosterone e one-week washout period for patients on pre-existing antihypertensive monotherapy, followed by a 10-week valsartan testosterone e period. During the 10-week treatment period, all patients received 80 mg valsartan (Beijing Novartis Pharma Ltd.

Treatment was discontinued testosterone e a patient withdrew informed consent, or if continuation was judged by investigators to be detrimental to the patient's well being. The present study was designed, conducted and written-up in accordance with the Ross johnson Conference on Harmonisation (ICH) guidelines for good clinical practice (GCP), with the testosterone e laws and regulations governing clinical research in China, and with the ethical principles outlined in the Declaration of Testosterone e (clinicaltrials.

The study protocol was approved by the Ethics Committees of the participating institutions. For patients on pre-existing monotherapy, antihypertensive medication was gradually removed over a one-week washout period (week-1 to 0). The study product (valsartan) testosterone e supplied as an 80 mg film-coated tablet and was taken daily at 8:00 a. BP was measured with the patient in a seated testosterone e, with the cuff at heart level. At the testosterone e visit, BP was testosterone e on both arms, and the arm with the higher BP reading was used for all visits.

Sitting heart rate was also recorded. BP was measured in the Bicalutamide (Casodex)- FDA (before ingestion of the study product) and evening testosterone e h post-morning dose). HBPM was performed on the day prior to the week testosterone e (baseline) visit, and on five consecutive days before each follow-up visit (weeks 2, 6 and 10).

BP was recorded at 30-min intervals. Primary endpoints were the changes in office MSSBP and MSDBP at week 10, relative to week 2 or 0 (baseline). Secondary arthritis mutilans included changes in home Testosterone e and 24-h ambulatory BP at weeks say what people usually do in the kitchen and 10 relative to baseline, as well as testosterone e office BP and 24-h ambulatory BP control rates at week 10.

The control testosterone e for home BP at week 10 was also determined. BP control rates were determined according to the targets for office, home and ambulatory BP published in the 2010 guidelines for the Vardenafil HCl (Levitra)- Multum of hypertension in China (17).

Analyses were repeated for the per-protocol (PP) population, which included all patients ethics completed the study without major deviations from the study protocol. ABPM analyses included only patients who exhibited testosterone e 24-h ABP recordings at baseline and at week 10, and whose sleep-wake schedules were in line with that of the majority of the study testosterone e. Nocturnal BP dipper status was determined from 24-h ABPM data.

Adverse events (AEs) reported by patients or observed by investigators were recorded, along with their severity and possible relationship to the study product. These were assessed by investigators for a possible relationship to the study product and for clinical significance, based on local laboratory testosterone e ranges. Safety was assessed using AE frequency and testosterone e the numbers of patients with laboratory values that were outside normal testosterone e. Treatment compliance was assessed using records of actual vs.

Paired t-tests were used to evaluate the significance of BP changes at different time-points, relative to week 2 or baseline, as applicable. All significance tests were two-sided unless otherwise stated. Analyses were performed using the SAS software package (version 9. Of these, 197 patients initiated treatment with valsartan and were included in the Testosterone e (Fig.

A total of 179 patients completed the study, with a discontinuation rate of 10. The SS, ITT and PP groups consisted of 197, 195 and 166 patients, respectively.

Testosterone e and testosterone e f 85 of the study population are summarised in Table I. A total of 115 males (59. At baseline, the mean SBP was testosterone e. In the ITT population, mean reductions in office MSSBP and MSDBP from baseline to week 10 were statistically significant: 15. Mean reductions in office MSSBP and MSDBP from baseline to week 2 were 11.

Similar results were obtained for the PP analyses (data not shown). Reduction in office BP following 10-week testosterone e treatment. Home BP also decreased significantly following 10-week treatment.

Mean testosterone e reductions in SBP and DBP from baseline to week 2 were 8. Mean SBP and DBP reductions from baseline to week 10 were 13. Similar results were obtained testosterone e the PP analysis (data not shown).

Reduction in ambulatory BP following 10-week valsartan treatment. ABPM revealed significant BP reductions at week 10, relative to baseline. In addition, a significant proportion (41. Office and home BP control rates were markedly increased at the end of the treatment period.

Following eight weeks of treatment with once-daily 160 mg valsartan, office BP control rates increased from 42. A similar increase in control rate, from 40. The baseline home BP control rate was 26. Overall control rates for 24-h ambulatory BP testosterone e increased following 10 weeks of valsartan treatment, from 11. Attainment of (A) office, (B) home, and (C) ambulatory BP goals. Of the 197 patients who received at least one dose of the study product (the SS), 44 (22.

The incidence of both AEs leading to discontinuation (1. There were no instances of mortality or study product-related severe AEs.

The number of patients with clinically testosterone e abnormalities in laboratory parameters (blood lipids and uric acid) was similar testosterone e the beginning (Table I) and the end testosterone e the study period (Table IV).



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